Talk: Stephen Wilson 4/4 3:30

Stephen Wilson, PhD
Vanderbilt

Wednesday, April 4, 2018
3:30-5:00pm
BOUS A106

Imaging the language network: functional neuroanatomy, acquired aphasia, and recovery

What is the functional architecture of the language network? How is it impacted by damage to its various nodes and connections? And when it is damaged, how can it reorganize to support recovery of language function? To address these questions, we have carried out a series of multimodal neuroimaging studies in individuals with acquired language deficits of diverse etiologies–stroke, neurodegenerative disease, and resective surgery–as well as neurologically normal volunteers. Our findings, along with those of others, reveal a complex, variegated language network in which numerous distinct regions and tracts in the temporal, frontal and parietal lobes play distinct functional roles. Yet the network is strikingly resilient to most patterns of damage, indicating that in many cases, functional specialization is graded rather than absolute. Our findings suggest that recovery from aphasia depends primarily on reconfiguration of spared language regions, rather than macroscopic reorganization of the whole system.

Talk: Evelina Fedorenko 3/28 3:30pm

Evelina Fedorenko, PhD
Assistant Professor
Harvard Medical School and Massachusetts General Hospital

Wednesday March 28, 2018
3:30-5:00pm, BOUS A106

The cognitive and neural architecture of the human language system

Brain regions that support high-level language processing are strikingly selective. This selectivity rules out a few prominent hypotheses — e.g., that left frontal lobe structures support language via domain-general executive processes, or that language relies on an abstract syntactic processing mechanism shared by other domains — but leaves open the nature of the exact computations that the language system supports. I will discuss three lines of work that, in tandem, suggest that the language network is fundamentally concerned with meaning, including both the processing of individual word meanings and semantic composition.
First, both lexical and combinatorial processing elicit robust responses throughout the fronto-temporal language network (e.g., Fedorenko et al., 2010; Blank et al., 2016). Further, some language regions show stronger responses to lexico-semantic processing and represent lexico-semantic information more robustly than structural information (Fedorenko et al., 2012), but no regions show the opposite pattern. In recent work (Mollica et al., in prep.), we further found that stimuli that are not well-formed but interpretable elicit as strong a response as intact sentences, in line with current sentence comprehension models whereby our interpretation mechanisms are robust to signal corruption (e.g., Levy et al., 2009; Gibson et al., 2013).
Second, intracranial recordings from the surface of the human brain show that neural activity, indexed by gamma power, increases monotonically over the course of a sentence across the language system (Fedorenko et al., 2016). Having ruled out a number of alternative explanations of this effect in terms of generic attention, working memory, and cognitive load, we argue that the most likely explanation is that this response increase reflects the increasing complexity of the evolving representation of the sentence meaning and is thus a candidate neural marker of complex meaning construction.
And third, we have recently developed a new approach for decoding linguistic meanings from the brain (Pereira et al., in press), based on a procedure for broadly sampling a semantic space constructed from massive text corpora. After the system was trained on imaging data of individual concepts, it could decode sentences from a wide variety of topics. These decoded representations were sufficiently detailed to distinguish even semantically similar sentences. Thus, we established the viability of using distributed semantic representations to probe meaning representations in the brain, laying a foundation for future development and evaluation of precise hypotheses about how concepts are represented and combined.
We encourage members of our MRI community, including students, to schedule a meeting; please email Inge-marie.eigsti@uconn.edu with your availability.

New England Research on Dyslexia Society Meeting October 21

The 3rd meeting of the New England Research on Dyslexia Society will be held in Storrs, CT on October 21, 2017. The meeting will take place on the University of Connecticut campus in Oak Hall.

KEYNOTE SPEAKER: John Gabrieli, Ph.D, Professor of Brain and Cognitive Sciences, MIT

“Dyslexia: From Neurophysiology to Intervention”

The New England Research Group on Dyslexia is an interdisciplinary community of researchers, educators, clinicians, and policy experts, whose work aims at elucidating the biological, including psychological, and social underpinnings of Developmental Dyslexia and related disorders with the objective of improving prevention, early detection, diagnosis, treatment/intervention and social support (including legal, political, and public health) associated with this learning disability.

Registration is closed.

 

BOLD Brownbag Series

BIRC is pleased to present a series of informal BOLD Brownbag talks, held on Wednesdays from 9-10 AM in Bous 162. If you are not currently on the MRI distribution list, but would like to hear updates about these talks, please join the list serve. This venue is an informal one, geared toward discussion of work in progress (especially methodological/analytical) rather than formal polished presentations of finished products (though we’ll have some of those as well!).

You can find the current schedule here.

Appointment of Dr. Roeland Hancock

The BIRC pleased to announce the appointment of Dr. Roeland Hancock as Associate Director of the Brain Imaging Research Center. Roeland received a PhD in Psychology from the University of Arizona. Since 2013, he has been a Postdoctoral Fellow at the University of California, San Francisco working with Fumiko Hoeft, an innovative leader in MRI research. Roeland has expertise in functional, structural and spectroscopic magnetic resonance imaging, as well software development, project management, and magneto/electroencephalography.

Roeland’s research interests concern the neurobiological factors underlying individual variability in language processing and the application of new mathematical and computational techniques to understanding these processes. His most recent work has focused on the effects of neurochemistry on the neural dynamics of speech and auditory processing.
Roeland’s appointment will begin on June 23.